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Abstract #1912

Increased midbrain iron deposition in Parkinsons disease measured by quantitative susceptibility mapping

Guangwei Du 1 , Tian Liu 2 , Mechelle M. Lewis 1,3 , Jeffrey Vesek 4 , Lan Kong 5 , Martin Styner 6 , Qing X. Yang 4,7 , and Xuemei Huang 1,4

1 Department of Neurology, Penn State Hershey Medical Center, Hershey, PA, United States, 2 MedImageMetric LLC, New York, NY, United States, 3 Department of Pharmacology, Penn State Hershey Medical Center, Hershey, PA, United States, 4 Department of Radiology, Penn State Hershey Medical Center, Hershey, PA, United States, 5 Public Health Sciences, Penn State Hershey Medical Center, Hershey, PA, United States, 6 Department of Computer Science, University of North Carolina, Chapel Hill, NC, United States, 7 Department of Neurosurgery, Penn State Hershey Medical Center, Hershey, PA, United States

Parkinsons disease (PD) is the second most common neurodegenerative disorder. Increased iron content in the substantia nigra (SN) of PD patients has been reported as a surrogate marker of PD. Quantitative susceptibility mapping (QSM) has been proposed to directly quantify iron content in human brain. In this work, we examine the use of QSM as an in vivo marker(s) of PD related pathology in nigrastriatal structures. Our results showed increased susceptibility in the SN and the RN in PD patients compared with controls. This study supports the hypothesis that QSM can measure iron accumulation associated with the PD-related pathological process.

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