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Abstract #1911

Single subject VBM analysis

Joao M. S. Pereira 1 , Julio Acosta-Cabronero 2 , Peter J. Nestor 2 , Guy B. Williams 3 , and Miguel Castelo-Branco 4

1 Laboratory of Biostatistics, IBILI - Faculty of Medicine, University of Coimbra, Coimbra, Portugal, 2 German Centre for Neurodegenerative Diseases (DZNE), Magdeburg, Germany, 3 Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom, 4 Visual Sciences Laboratory, IBILI - Faculty of Medicine, University of Coimbra, Coimbra, Portugal

Voxel based morphometry (VBM) is a common brain imaging tool used in research to detect differences in the volume of brain tissues between groups. Its application to a clinical setting has been hampered by its inability to assess single subjects. This work presents a proof of concept of single subject VBM, using a nonlinear registration algorithm to simulate normal anatomical variability and thus generate a sample of subjects out of a single scan.

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