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Abstract #1888

Failure of connectivity modulation during an attentional task in children with epilepsy is not explained fully by interictal activity

Elhum Shamshiri 1 , Maria Centeno 1 , Kelly St Pier 2 , Suejen Perani 1 , Helen Cross 3 , and David Carmichael 1

1 UCL Institute of Child Health, London, UK, United Kingdom, 2 Epilepsy Unit, Great Ormond Street Hospital, London, UK, United Kingdom, 3 Neurosciences Unit, UCL Institute of Child Health, London, UK, United Kingdom

The current study looks at aberrant cognitive networks previously established in children with epilepsy by exploring the task-related differences between patients and controls during a natural stimulus and resting state. We used a GLM in SPM8 as well as functional connectivity looking at temporal changes in BOLD response to analyse the results. Significant differences between groups are found in the dorsal anterior cingulate cortex. Additionally, connectivity results showed that patients recruit more brain regions than controls in performing cognitive tasks, and that patients are also shown to have problems with task switching and cognitive network modulation when compared to controls.

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