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Abstract #1887

Impact of Hypertension and Aging on Resting State BOLD Response to Heart Rate Variation

Wendy W Ni 1 , Catie Chang 2 , Hesamoddin Jahanian 3 , Gary H Glover 3 , and Greg Zaharchuk 3

1 Department of Electrical Engineering, Stanford University, Stanford, CA, United States, 2 Advanced MRI Section, LFMI, NINDS, NIH, Bethesda, MD, United States, 3 Department of Radiology, Stanford University, Stanford, CA, United States

Cardiac contribution to resting state BOLD signal fluctuations may be modeled as a linear response to heart rate variation using the RVHR model. In this study, we interpret three features of the response function as indicators of the strength of cerebrovascular autoregulation, and examine the differences between young normals, elderly subjects with hypertension and chronic kidney disease, and elderly normals. We find statistically significant differences in response strength between young and elderly normals, and between elderly normals and patients. Our numerical results also suggest that aging reduces autoregulation, while hypertension obscures the effect of aging on BOLD signal fluctuations.

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