Abstract #1884
Effect of short-term synaptic plasticity on the relationship between neuronal activity, BOLD, CMRO2 and CMRGlc studied by metabolic modeling of neuron-glia interaction
Mauro DiNuzzo 1,2 , Silvia Mangia 3 , Bruno Maraviglia 1,4 , and Federico Giove 1,2
1
MARBILab, Enrico Fermi Center, Rome, Rome,
Italy,
2
Department
of Physics, U Sapienza, Rome, Rome, Italy,
3
CMRR,
U Minnesota, Minneapolis MN, United States,
4
Santa
Lucia Foundation IRCCS, Rome, Italy
We developed a kinetic model of rat brain metabolism
including electrophysiological information related to
short-term synaptic plasticity in order to examine the
coupling between neuronal activity, BOLD, and cerebral
metabolic rates of oxygen (CMRO2) and glucose (CMRGlc).
We found that post-synaptic activity correlates with
CMRO2 and BOLD, while pre-synaptic spiking activity
correlates with CMRGlc. In particular, axonal action
potentials, albeit consuming less energy than dendritic
excitatory postsynaptic potentials, are found to be the
primary determinants for the decrease in oxygen/glucose
index at firing rates above 4-6 Hz. Our results are
relevant for further understanding neurovascular and
neurometabolic coupling.
This abstract and the presentation materials are available to members only;
a login is required.
Join Here
