Meeting Banner
Abstract #1869

Longitudinal microstructural white matter changes in a transient focal ischemic stroke rat model using a tract-based spatial statistics (TBSS) method

Won Beom Jung 1 , Jae Hun Kim 2 , Geun Ho Im 1 , Moon Sun Jang 1 , Kyoung Nam Kim 1 , Julius Juhyun Chung 3 , Sun Young Chae 3 , and Jung Hee Lee 1,2

1 Center for Molecular and Cellular Imaging, Samsung Biomedical Research Institute, Samsung Medical Center, Seoul, Korea, 2 Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea, 3 Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University, Seoul, Korea

In this study, we examined the microstructural white matter changes after ischemia in rats over time from acute (4 hours) and sub-acute (1 week) to chronic (3 and 6 weeks) stages using tract-based spatial statistics (TBSS) method. The frectional anisotropy (FA) values decreased in perilesional white matter tracks at sub-acute stage and gradually normalized from corpus callosum to external capsule at later stages. In addition, the mean diffusivity (MD) values decreased at acute stage and dramatically increased at later stages. We believe that the longitudinal FA changes ranging from decrease to normalization may reflect the recovery of ischemic brain damage by WM restoration.

This abstract and the presentation materials are available to members only; a login is required.

Join Here