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Abstract #1868

Evolution of Fractional Anisotrophic Changes In An Animal Model of Ischemic Stroke: Relative Contribution of Anisotropic Versus Magnitude Diffusivity

Cheng-Yu Chen 1,2 , Duen-Pang Kuo 3,4 , Hsiao-Wen Chung 4 , Chen Chang 5 , and Ping-Huei Tsai 1

1 Department of Medical Imaging and Imaging Research Center, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan, 2 Graduate Institue of Clinical Medicine, Taipei Medical University, Taipei, Taiwan, 3 Department of Radiology, Taoyuan Armed Forces General Hospital, Taoyuan, Taiwan, 4 Graduate Institute of Biomedical Electrics and Bioinformatics, National Taiwan University, Taipei, Taiwan, 5 Functional and Micro-magnetic Resonance Imaging Center, Academic Sinica, Taipei, Taiwan

Although FA is one of the most common indices used in diffusion tensor imaging reflecting the brain microstructural changes, the FA changes in acute ischemic stroke may not be specific due to two components, q and L, included. Therefore, the aim of our study is to investigate the differential behaviors of q and L in the ischemic penumbra versus the infarct core using a longitudinal rat stroke model. Our preliminary result suggests that q may detect stroke-related abnormality with a higher sensitively than L, and the relative stable q in ischemic penumbra may provide insight into the definition of salvageable brain tissue in hypoperfused brain at acute setting.

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