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Abstract #1841

Cortical Phase Shifts in Healthy Aging at 7 Tesla

Mathijs Buijs 1 , Nhat Trung Doan 2 , Sanneke van Rooden 1 , Maarten Versluis 1 , Julien Milles 2 , Jeroen van der Grond 1 , and Mark van Buchem 1

1 Radiology, Leiden University Medical Center, Leiden, Netherlands, 2 Division of Image Processing (LKEB), Leiden University Medical Center, Leiden, Netherlands

In recent years phase imaging has become available as a method of measuring iron in vivo. Scanning at 7 Tesla has increased the usability of phase images for smaller structures. The aim of this study was to investigate the appearance of phase contrast in the cerebral cortex in normal aging. We scanned three different age groups and measured cortical phase values using an in-house developed tool. Our study shows an increase in paramagnetic phase shift with age in the cerebral cortex of healthy subjects at 7T. The most significant increase in phase shift is seen between middle and old age.

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