Meeting Banner
Abstract #1840

Is the rate of change in fractional anisotropy with age constant within white matter tracts? A study of two segments of the Cingulum bundle

Johanna Mrtensson 1 , Jimmy Ltt 2 , Danielle van Westen 3 , Elna-Marie Larsson 1 , and Markus Nilsson 4

1 Radiology, Radiology, Oncology and Radiation Science, Uppsala, Uppsala, Sweden, 2 Center for Medical Imaging and Physiology, Skne University Hospital, Lund, Lund, Sweden, 3 Diagnostic Radiology, Skne University Hospital, Lund, Lund, Sweden, 4 Lund University Bioimaging Center, Lund University, Lund, Lund, Sweden

We divide cingulum into two segments and examine the patterns of age-related WM changes in fractional anisotropy (FA) within the segments. The purpose is to investigate whether an antero-posterior gradient in the rate of ageing is present. DTI-MRI was performed on 80 volunteers and FA within the segments analysed as functions of age. FA in the anterior segment decreased 18% between the age of 30 and 83, while FA in the posterior segment decreased 8.3%. Differences in age-related changes may be partly explained by the retrogenesis hypothesis in case cingulum is composed of separate tracts and agrees with antero-posterior maturation.

This abstract and the presentation materials are available to members only; a login is required.

Join Here