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Abstract #1814

4D Flow MRI to quantify cerebral blood flow during environmental challenges

J. Mikhail Kellawan 1 , John W Harrell 1 , Alejandro Roldan-Alzate 2 , Cameron Rousseau 1 , Oliver Wieben 2 , and William G Schrage 1

1 Department of Kinesiology, University of Wisconsin - Madison, Madison, Wisconsin, United States, 2 Departments of Medical Physics and Radiology, University of Wisconsin - Madison, Madison, Wisconsin, United States

Purpose: To quantify total and regional cerebral blood flow (CBF) in humans to hypoxia and cyclooxygenase inhibition (Indomethacin). Methods: After baseline scans (4D flow MRI), subjects breathed 10% oxygen to reduce arterial saturation (~83%). Hypoxia duration was 10 minutes with 4D PC VIPR scan from min 5-10. Results: Segmentation quality of angiograms was excellent. CBF increased with hypoxia; the increase was 3x greater in women. Indomethacin reduced or increased CBF in a sex and artery specific manner. Summary: 4D flow MRI can quantify CBF in the entire cerebrovascular system and with high spatial resolution and physiologic functional data.

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