Abstract #1811
Inhibitory Functioning in Fear Extinction: GABA and BOLD Responses
Nina Levar 1,2 , Nicolaas A. J. Puts 3,4 , Judith van Leeuwen 1,2 , Damiaan Denys 1 , and Guido A. van Wingen 1,2
1
Department of Psychiatry, Academic Medical
Center, Amsterdam, Noord-Holland, Netherlands,
2
Brain
Imaging Center, Academic Medical Center, Amsterdam,
Noord-Holland, Netherlands,
3
Russell
H. Morgan Department of Radiology and Radiological
Sciences, The Johns Hopkins University, Baltimore,
Maryland, United States,
4
FM
Kirby Center for Functional Brain Imaging, Russell H.
Morgan Department of Radiology and Radiological
Sciences, Baltimore, Maryland, United States
The GABAergic system is thought to play a key role in
the regulation of fear and its dysregulation may
contribute to the development of pathological anxiety.
We performed a multimodal imaging study combining
gamma-aminobutyric acid (GABA) magnetic resonance
spectroscopy (MRS) with functional MRI in order to
investigate the impact of individuals differences in
dorsal anterior cingulate cortex (dACC) GABA
concentrations on BOLD activity during extinction
learning. A correlation analysis showed that healthy
participants with low dACC GABA levels displayed reduced
extinction learning to an aversive stimulus at trend
level.
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