Development of cortical hubs in childhood and adolescence: a graph theoretical analysis in fMRI
Benjamin R Morgan 1 , George M Ibrahim 1,2 , Wayne Lee 1 , and Margot J Taylor 1,2
Hospital for Sick Children, Toronto,
of Toronto, Toronto, Ontario, Canada
Whole-brain graph theoretical analysis was used in
resting state fMRI data to identify brain regions that
become stronger network hubs with age. 104 healthy
subjects between the ages of 7 and 22 years were scanned
and their EC maps were correlated with age.
Non-parametric testing revealed that the posterior
cingulate and ventromedial prefrontal cortices become
significantly stronger hubs with age, while the frontal
lobes and subcortical structures become significantly
weaker hubs during a critical period of development.
EC-based developmental analyses are a novel approach to
evaluating network development and may provide further
insight into areas of vulnerability for developmental
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