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Abstract #1735

Resting-state functional MRI for evaluation of brain development from childhood to young adulthood

Mengxing Wang 1 , Jing Zhang 1 , Guohua Shen 1 , Jilei Zhang 1 , Kaihua Zhang 1 , Guang Yang 1 , and Xiaoxia Du* 1

1 Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University, Shanghai, Shanghai, China

We investigated the developmental aspects of local intrinsic activity, functional connectivity (FC) from childhood to young adulthood using resting-state functional MRI. There were three groups participated in this study: 20 children, 20 adolescents and 23 young adults. The amplitude of low-frequency fluctuation (ALFF) significant changes were mainly in frontal lobe, limbic lobe and cerebellum posterior lobe among three groups. The FC difference were in frontal lobe (superior, inferior and medial frontal gyri), cerebellum posterior lobe, parietal lobe (inferior parietal lobule and postcentral gyrus), as well in insula, caudate and anterior cingulate among three groups.

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