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Abstract #1730

Correcting Myelin Water Fraction for T2 Changes Caused by Varying Phosphate Buffer Concentration in Aldehyde Fixed Spinal Cord Tissue

Henry Szu-Meng Chen 1,2 , Nathan Holmes 3 , Wolfram Tetzlaff 3,4 , and Piotr Kozlowski 3,5

1 UBC MRI Research Centre, Vancouver, British Columbia, Canada, 2 Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, 3 ICORD, Vancouver, BC, Canada, 4 Zoology, University of British Columbia, Vancouver, BC, Canada, 5 Radiology, University of British Columbia, Vancouver, BC, Canada

This study looked at the impact of phosphate buffer (PB) concentration on MR measurements of myelin water fraction (MWF) in ex vivo rat spinal cord. The results show that T2 shortens as the concentration of PB decreases, which lead to a decrease in T2 of both the intra/extracellular and myelin water peak that inflate the measured MWF. The effect can corrected for by moving the upper bound of myelin water T2 range to the mean T2 of the two peaks as long as the myelin water T2 is long enough to be well characterized by the given echo time.

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