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Abstract #1716

Singleshell diffusion MRI NODDI with in vivo cervical cord data

Francesco Grussu 1 , Torben Schneider 1 , Hui Zhang 2 , Daniel C. Alexander 2 , and Claudia A. M. Wheeler-Kingshott 1

1 NMR Research Unit, Department of Neuroinflammation, Queen Square MS Centre, UCL Institute of Neurology, London, England, United Kingdom, 2 Department of Computer Science and Centre for Medical Image Computing, University College London, London, England, United Kingdom

Neurite Orientation Dispersion and Density Imaging (NODDI) is a novel diffusion MRI technique which relies on doubleshell acquisition. To date, it is not clear whether a reduced NODDI model could be fitted to singleshell diffusion data of areas such as the spinal cord. In this work, we compare singleshell estimates of NODDI parameters to doubleshell ground truth in the healthy cervical cord in vivo, and our results would be informative for retrospective NODDI analysis of in vivo singleshell diffusion data of the same area.

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