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Abstract #1715

Resting state functional connectivity in the human cervical spinal cord at 7 Tesla: preliminary results across healthy controls

Robert L Barry 1,2 , Seth A Smith 1,2 , Adrienne N Dula 1,2 , and John C Gore 1,2

1 Vanderbilt University Institute of Imaging Science, Nashville, TN, United States, 2 Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States

Blood oxygenation level dependent signal fluctuations in the resting brain have been exploited to characterize low-frequency functional connectivity within specific neural circuits. However, there have been no previous rigorous reports of resting state correlations in the spinal cord. In a cohort of healthy controls we observed robust functional connectivity between left and right ventrolateral (motor) horns, and left and right dorsal (sensory) horns. No statistically significant correlations are observed between spinal gray and white matter, suggesting that observed correlations between gray matter horns cannot be simply attributed to spatially correlated physiological noise and likely represent genuine connectivity.

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