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Abstract #1674

14 T NMR and 7 T MRI in vitro investigation of cold stimulation of abdominal WAT, inguinal WAT and BAT

Alexander Brunner 1 , Daniela Strzoda 2 , Karel D. Klika 3 , Mathies Breithaupt 1 , Vanessa Stahl 1 , Stephan Herzig 2 , and Armin M. Nagel 1

1 Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 2 Molecular Metabolic Control, German Cancer Research Center (DKFZ), Heidelberg, Germany, 3 Molecular Structure Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany

Based on its unique thermogenic capacity, brown adipose tissue (BAT) shows very high potential to serve as a therapeutic node in the treatment of metabolic disorders, e.g., obesity. Recently, the BOLD effect T2*-weighted MRI during cold stimulation was used to detect cold-activated BAT in human individuals [1]. In this work, we compared 14 T NMR spectra and, for the first time, water fat fraction (WFF) [2], T1, T2 values measured in vitro by 7 T MRI between BAT, inguinal white adipose tissue (iWAT) and abdominal white adipose tissue (aWAT) in cold-stimulated mice and normal mice.

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