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Abstract #1496

Transverse Relaxation Amplified by Chemical Exchange (TRACE): A New Method for Mapping Molecular Integrity of Cartilage

Anup Singh 1 , Ravi Prakash Nanga 1 , Mohammad Haris 1,2 , Kejia Cai 1,3 , Felik Kogan 1 , Hari Hariharan 1 , and Ravinder Reddy 1

1 Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2 Research Branch, Sidra Medical and Research Center, Doha, Qatar, 3 Radiology, University of Illinois at Chicago, Chicago, IL, United States

Objective of current study was to develop a new method for mapping molecular integrity of cartilage based upon Transverse Relaxation Amplified by Chemical Exchange (TRACE). This simple and time efficient method provides a quantitative index of macromolecular content of cartilage and is less sensitive to fluid changes associated with pathological conditions of the tissue. The method was tested in chondroitin sulfate (CS) phantoms with different concentrations and pH as well as on human knee cartilage at 3T and 7T whole body MR scanners.

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