Magnetic Resonance Evaluation of Multiple Myeloma at 3.0 Tesla: How Do Bone Marrow Plasma Cell Percentage and Selection of Protocols Affect Lesion Conspicuity?
Miyuki Takasu 1 , Yoko Kaichi 1 , Chihiro Tani 1 , Shuji Date 1 , Yuji Akiyama 1 , Yoshiaki Kuroda 2 , Akira Sakai 3 , and Kazuo Awai 1
Diagnostic Radiology, Hiroshima University
Hospital, Hiroshima, Hiroshima, Japan,
Hiroshima University Hospital, Hiroshima, Japan,
Life Sciences, Fukushima Medical University School of
Medicine, Fukushima, Japan
The present study compared three fat-suppression
techniques in terms of CNR and percent contrast and
assessed the dependence of lesion conspicuity on BMPC%
obtained from biopsy specimen. Significant negative
correlations between percent contrast and CNR with BMPC%
were demonstrated. We attributed this finding to
increased signal intensity of background BM mainly
caused by T2 prolongation by diffusely infiltrated
myeloma cells, which can reduce the signal intensity
contrast between focal lesion and background BM. In the
low tumor load BM group, BM-focal lesion percent
contrast was significantly greater for FS-T2 FSE than
for the water image of IDEAL and STIR.
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