Abstract #1200
Registration-Based Motion Correction in Time-Series Studies of Bone Microarchitecture and Mechanics
Ning Zhang 1 , Jeremy F Magland 1 , Chamith S Rajapakse 1 , Hee Kwon Song 1 , and Felix W Wehrli 1
1
University of Pennsylvania, Philadelphia,
PA, United States
Subject motion degrades image quality. Intra-scan
subject motion can further mask detectability of
treatment effects in time-series studies. Here we
present a registration-based technique designed to
retrospectively correct for rigid-body intra-scan
subject motion. Results from in-vivo micro-MR images of
the distal radius show significant improvements in both
image quality and serial reproducibility on
image-derived trabecular bone micro-structure and
biomechanics compared to the navigator-based and
autofocusing techniques.
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