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Abstract #1142

Simultaneous Hyperpolarized 13C Pyruvate and Urea Perfusion Parameterizations in Cancer

Naeim Bahrami 1 , Cornelius Von Morze 1 , Christine Leon 1 , Daniel B. Vigneron 1 , and Peder E.Z. Larson 1

1 Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, United States

In cancerous tissue there is both existing vasculature and neovascularization as different kinds of lesions surpass the normal blood supply, including small circulation disturbance in some of the abnormal vessels. The variation of pyruvate perfusion and urea perfusion can be observed for the healthy and cancerous tissues. The urea perfusion is primarily representing the vasculature delivery in each specific tissue and it stays in the vessels, while the pyruvate perfusion,which is the accumulation of all source and derived metabolites related to the pyruvate including pyruvate,lactate and alanine, can also be a marker for vascular delivery but also includes tissue uptake.

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