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Abstract #1141

Dynamic 3D Compressed Sensing MR of hyperpolarized 13C Pyruvate and Urea in Prostate Cancer Models

Hsin-Yu Chen 1 , Peder E. Z. Larson 2 , Cornelius von Morze 2 , Christine Leon Swisher 1 , Naeim Bahrami 2 , Robert Bok 2 , John Kurhanewicz 1,2 , and Daniel B. Vigneron 1,2

1 Graduate Program in Bioengineering, UCSF and UC Berkeley, San Francisco, California, United States, 2 Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, United States

Use of 3D compressed-sensing [13C]pyruvate and [13C]urea MRSI sequence and dynamic models enables, for the first time, simultaneous evaluation of metabolic and perfusion parameters kpl and ktrans in a preclinical prostate tumor model. We demonstrates increases in both pyruvate-to-lactate conversion rate and perfusion/permeability in prostate tumor versus normal tissue. This approach shows great potential for the quantitative assessment of prostate cancer aggressiveness and also treatment response.

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