Abstract #1125
MRI guided drug delivery targeting glioma using inteleukin-13 conjugated liposome (IL-13-Liposome)
Xiaoli Liu 1 , Achuthamangalam Madhankumar 1 , Patti Miller 2 , Becky Webb 1 , Susan Hafenstein 3 , Elias Rizk 1 , James Connor 1 , and Qing Yang 4
1
Neurosurgery, Pennsylvania State College of
Medicine, Hershey, PA, United States,
2
Radiology,
Pennsylvania State College of Medicine, Hershey, PA,
United States,
3
Medicine, Pennsylvania State
College of Medicine, Hershey, PA, United States,
4
Pennsylvania
State College of Medicine, Hershey, PA, United States
There is a critical need for MRI guided drug delivery
for treating glioma. We developed a liposome
specifically targeting glioma using interlukin-12
receptors as the target for the tumor cells
(IL-13-Liposome). Our in vivo and in vitro data
demonstrated that our targeted liposome is capable of
delivering anticancer drug and MRI contrast agent to the
tumor cells at the same time.
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