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Abstract #1125

MRI guided drug delivery targeting glioma using inteleukin-13 conjugated liposome (IL-13-Liposome)

Xiaoli Liu 1 , Achuthamangalam Madhankumar 1 , Patti Miller 2 , Becky Webb 1 , Susan Hafenstein 3 , Elias Rizk 1 , James Connor 1 , and Qing Yang 4

1 Neurosurgery, Pennsylvania State College of Medicine, Hershey, PA, United States, 2 Radiology, Pennsylvania State College of Medicine, Hershey, PA, United States, 3 Medicine, Pennsylvania State College of Medicine, Hershey, PA, United States, 4 Pennsylvania State College of Medicine, Hershey, PA, United States

There is a critical need for MRI guided drug delivery for treating glioma. We developed a liposome specifically targeting glioma using interlukin-12 receptors as the target for the tumor cells (IL-13-Liposome). Our in vivo and in vitro data demonstrated that our targeted liposome is capable of delivering anticancer drug and MRI contrast agent to the tumor cells at the same time.

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