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Abstract #1094

Pulsed-continuous arterial spin labeling MRI with multiple post-labeling delay in renal cell carcinoma: clinical feasibility and initial results of a comparative study with parametric dynamic contrast-enhanced MRI

Nobuyuki Kosaka 1 , Katsuki Tsuchiyama 2 , Kazuhiro Shimizu 1 , Yasuhiro Fujiwara 3 , Tsuyoshi Matsuda 4 , Tatsuya Yamamoto 1 , Tatsuro Tsuchida 1 , Nobuyuki Oyama 2 , and Hirohiko Kimura 1

1 Department of Radiology, University of Fukui, Eiheiji, Fukui, Japan, 2 Department of Urology, University of Fukui, Eiheiji, Fukui, Japan, 3 Radiological Center, University of Fukui Hospital, Eiheiji, Fukui, Japan, 4 Global MR Applications and Workflow, GE Healthcare Japan, Hino, Tokyo, Japan

Pulsed-continuous arterial spin labeling MRI (pcASL) with multiple post-labeling-delay to measure arterial transit time-corrected tumor blood flow (ATC-TBF) in renal cell carcinoma was performed and compared to parametric dynamic contrast-enhanced MRI (DCE-MRI). All image acquisitions and data post-processings were successfully achieved in all 6 patients, and high signals of 5 clear cell carcinomas were visually identified. Both maximum slope and contrast enhancement ratio correlated significantly with ATC-TBF. K trans , v e , and IAUGC 90 @showed positive but non-significant correlations. pcASL with multiple PLD appears clinically feasible for measuring ATC-TBF, which correlated with several hemodynamic parameters of DCE-MRI.

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