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Abstract #1084

The effect of choline kinase-α inhibition on lipid metabolism of breast cancer cells

Noriko Mori 1 , Flonn Wildes 1 , Kristine Glunde 1 , and Zaver M. Bhujwalla 1

1 The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States

Phosphatidylcholine has important roles in membrane structure and cell signaling. Increased levels of choline kinase (Chk)-α and phosphocholine (PC) are consistently observed in aggressive cancers. Understanding the roles of Chk-α in cancer can result in new therapies. We previously showed that the Chk-α protein, but not PC was essential for cell survival of two triple negative breast cancer cell lines, MDA-MB-231 and SUM149, using a Chk-α inhibitor which reduces PC but not Chk-α protein. Here we have investigated lipid metabolism in these breast cancer cells and identified PtdCho as an important factor in breast cancer cell survival.

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