Abstract #1056
Longitudinal variation of fibroglandular tissue and background parenchymal enhancement on breast MRI in high-risk women: a quantitative assessment
Shandong Wu 1 , Wendie A. Berg 2 , Margarita L. Zuley 2 , Jules Sumkin 2 , Rachel C. Jankowitz 3 , and David Gur 4
1
Radiology, University of Pittsburgh,
Pittsburgh, PA, United States,
2
Radiology,
University of Pittsburgh Medical Center Magee-Womens
Hospital, PA, United States,
3
Oncology,
University of Pittsburgh Medical Center Magee-Womens
Hospital, PA, United States,
4
Radiology,
University of Pittsburgh, PA, United States
The purpose of this study is to perform quantitative
assessment on the longitudinal variation of
fibroglandular tissue (FGT) and background parenchymal
enhancement (BPE) in sequential breast MRI scans for a
cohort of high-risk women of developing breast cancer
who did not undergo any specific risk-reduction
intervention. We retrospectively analyzed 71 high-risk
women each with two longitudinal cancer-free MRI scans
using a fully automated computerized method. The
preliminary results demonstrate the temporal variability
of FGT and BPE, which may be useful as a reference
measure when investigating these parameters as risk
predictors and possibly as indicators of
intervention-response in high-risk women.
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