Abstract #1055
High Spatial Resolution DTI Sequence for Characterizing Breast Tumor Early Treatment Response: Comparison to Standard DTI Sequence
Lisa Wilmes 1 , Wei Ching Lo 2 , David C Newitt 2 , Suchandrima Banerjee 3 , Evelyn Proctor 2 , Emine Saritas 4 , Ajit Shankaranarayanan 3 , and Nola M Hylton 2
1
University of California San Francisco, San
Francisco, CA, United States,
2
University
of California San Francisco, CA, United States,
3
Applied
Science Laboratory GE Healthcare, CA, United States,
4
University
of California Berkeley, CA, United States
A high-resolution reduced field of view diffusion tensor
weighted imaging sequence (HR-DTI), voxel size 4.8 mm3,
was optimized for breast imaging and compared to a
standard FOV DTI sequence (STD-DTI), voxel size 29.3
mm3, for evaluating tumor response to treatment in seven
breast cancer patients undergoing neoadjuvant
chemotherapy. Significant differences were found between
the tumor fractional anisotropy (FA) measured by HR-DTI
and the STD-DTI prior to and early in treatment. Of the
DTI parameters evaluated, HR-DTI FA correlated most
strongly with tumor volume change post treatment. This
preliminary study suggest that HR-DTI may be sensitive
to treatment-induced changes in tumors.
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