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Abstract #1020

Simultaneous fPET and fMRI for Assessing Dynamic Neurovascular and Neurometabolic Changes

Hsiao-Ying Wey 1 , Marjorie Villien 1 , Joseph B Mandeville 1 , Bruce R Rosen 1 , and Jacob M Hooker 1

1 A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States

BOLD fMRI only probes neural activity indirectly and the signal reflects a composite change of neurovascular and neurometabolic coupling. Complete measurements of changes in hemodynamic responses and oxidative and non-oxidative glucose metabolisms in response to stimuli or tasks will facilitate our interpretation of brain function. In this study, we circumvent the temporal limitation of FDG PET and reinvent its use to enable a truly dynamic detection of glucose metabolism. In addition, we validate our approaches using global physiological challenges. Together with simultaneously acquired BOLD/ASL data and hypercapnic calibration, a wealth of information can be obtained in one scan.

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