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Abstract #1019

ATP signaling plays a key role in the BOLD Response

Jack A Wells 1 , Isabel N Christie^ 1 , Nephtali Marina 2 , Melina F Figueiredo 3 , Anya G Teschemacher 3 , Sergey Kasparov 3 , Alexander V Gourine* 2 , and Mark F Lythgoe* 1

1 Centre for Advanced Biomedical Imaging, University College London, London, London, United Kingdom, 2 Neuroscience, Physiology and Pharmacology, UCL, London, United Kingdom, 3 School of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom

Understanding the mechanisms of neurovascular coupling is essential to the interpretation of fMRI BOLD signals. Astrocytes communicate via release of ATP, however its role neurovascular coupling has not been considered. To explore the contribution of ATP-mediated signalling in generation of BOLD responses, we developed a lentiviral vector that degrades ATP, effectively preventing its action. During bilateral forepaw stimulation, a smaller BOLD response was observed in the forepaw region transduced to express TMPAP relative to the control side. These novel data indicate that astroglial ATP-signalling is important for neurovascular coupling in the intact brain.

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