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Abstract #1015

Measuring Changes in Arterial and Venous Cerebral Blood Volume in Human Brain at 7T

Laurentius Huber 1 , Aneurin Kennerley 2 , Dimo Ivanov 3 , Claudine Gauthier 1 , Harald E. Mller 1 , and Robert Turner 1

1 Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 2 Department of Psychology, The University of Sheffield, United Kingdom, 3 Psychology and Neuroscience, Maastricht University, Netherlands

A CBV- and BOLD-sensitive multi-echo VASO sequence is used to estimate arterial and venous CBV changes. Separation between vascular compartments can be achieved by modeling their T2* and oxygenation-dependent signal contribution across TEs in MR images with and without selective blood nulling. Spatiotemporal features of arterial and venous CBV and their interaction with CBF and BOLD responses is considered with respect to position across the cortical ribbon, the post-stimulus undershoot and sustained neural inhibition. It is concluded that these features differ across time, stimulus type and vessel type.

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