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Abstract #1014

Cerebral Blood Flow MRI and CBF fMRI of Rat Brain up to 50x38x1000μm

Qiang Shen 1 , Shiliang Huang 1 , and Timothy Q Duong 1

1 Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States

We previously reported high spatial resolution basal CBF maps of rat brain at 75x56x1000μm. In this study, we further pushed the spatial resolution to 50x38x1000μm for basal CBF imaging. Moreover, we also investigated lamina-specific CBF fMRI responses in a rat forepaw stimulation model. Comparison was made with lamina-specific BOLD fMRI responses. High resolution CBF map showed remarkable columnar and layer specific perfusion information in the cortex. Layer IV and VI showed higher CBF, likely associated with higher basal metabolic needs. The CBF fMRI responses peaked broadly in layer IV-V, whereas the BOLD fMRI responses peaked in the superficial layers.

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