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Abstract #1012

Vessel-specific mapping of cerebral venous oxygenation of small veins

Lisa C. Krishnamurthy 1,2 and Hanzhang Lu 1

1 Advanced Imaging Research Center, UT Southwester Medical Center, Dallas, TX, United States, 2 Dept. of Bioengineering, University of Texas at Arlington, Arlington, TX, United States

The ability to generate a small-vessel map of Yv may help in better characterizing variations in venous oxygenation across brain regions, identifying regions at risk of ischemia attack or stroke, and may find immediate applications in clinical conditions that affect specific brain regions. The present study aims to optimize a sequence called T2-Relaxation-Under-Phase-Contrst (TRU-PC) MRI to generate a complete Yv map of the vasculature in the mid-sagittal brain, including small veins (1-2 mm in caliber). The optimization includes removing an eddy-current induced artifact to improve the Yv quantification, adding additional scans to sensitize the maps to more vessels, and merging these scans into a single signal map for T2-fitting.

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