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Abstract #1011

Mapping the Distinct Single-Vessel Vascular Contribution to BOLD and CBV fMRI

Xin Yu 1 , Stephen J. Dodd 1 , Afonso C. Silva 1 , and Alan P. Koretsky 1

1 National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States

Hemodynamic signal from individual venules can be detected directly with fMRI. Here, the hemodynamic signal from BOLD and CBV fMRI was measured at high temporal (100ms) and spatial (150x150m) resolution in layers 4/5 of the rat forepaw S1 with a fast gradient-echo MRI sequence. Distinctly different voxels were activated in BOLD vs CBV fMRI. In contrast to the BOLD activated voxels primarily located within penetrating venules, CBV activated voxels were primarily located to penetrating arterioles. This result makes it possible to directly image the CBV and BOLD response at the level of single-vessels to better understand neurovascular coupling.

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