Co-transplantation of encapsulated human mesenchymal stem cells improves the viability of human islet xenografts in a mouse model of type I diabetes
Mangesh Kulkarni 1,2 , Dian Arifin 1,2 , and Jeff Bulte 1,2
Institute for Cell Engineering, the Johns
Hopkins University School of Medicine, Baltimore,
Maryland, United States,
H. Morgan Department of Radiology and Radiological
Science, Division of MR Research, Baltimore, Maryland,
Transplantation of microencapsulated islets circumvents
the need for immunosuppression which is a requirement
for the clinically used Edmonton protocol. We developed
complementary strategies to improve transplant survival.
Incorporation of perfluorocarbons within the capsules
enabled in vivo monitoring using 19F MRI following
subcutaneous implantation of human islets in a mouse
model of type I diabetes mellitus. In this xenogeneic
environment, encapsulated human islet viability was
significantly improved following co-transplantation with
encapsulated human MSCs.
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