Abstract #0990
Real-time assessment of the effect of acute and chronic hypoxia on cardiac metabolism in the control and diabetic rat: an in vivo study
Lydia Le Page 1 , Oliver Rider 2 , Victoria Noden 1 , Andrew Lewis 2 , Latt Mansor 1 , Lisa Heather 1 , and Damian Tyler 1
1
Department of Physiology, Anatomy and
Genetics, University of Oxford, Oxford, United Kingdom,
2
Oxford
Centre for Clinical Magnetic Resonance Research, Oxford,
United Kingdom
Diabetes is associated with a high risk of
cardiovascular disease and hypoxia is potentially an
important component of this risk. Here, we investigated
the
in vivo
, real-time metabolic response of the
diabetic rat heart to acute and chronic hypoxia. Acute
hypoxia reduced pyruvate dehydrogenase (PDH) flux and
increased lactate production in control hearts but this
did not occur in diabetic hearts. Following chronic
hypoxia, neither group showed alterations in cardiac PDH
flux or lactate production. We have shown an acute
metabolic inflexibility in the
in
vivo
diabetic
heart, which is possibly overcome over a longer hypoxic
period by physiological adaptations.
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