Abstract #0918
Evidence for Caution in DCE-MRI Assessment of Response to Antiangiogenic Therapy Using the Reference Tissue Method
Wei Huang 1 , Aneela Afzal 1 , Megan L Holtorf 1 , and Christopher W Ryan 1
1
Oregon Health & Science University,
Portland, Oregon, United States
DCE-MRI studies were performed on eight soft-tissue
sarcoma patients to assess responses to treatment
regimen of antiangiogenic agent plus conventinal
chemoradiotherapy. Significant Ktrans and kep decreases
were found in normal muscle regions adjacent to the
tumor following initial 2 weeks of antiangiogenic
therapy only. The results suggest that caution must be
taken in DCE-MRI evaluation of response to
antiangiogenic treatment using the reference tissue
method.
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