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Abstract #0896

Quantitative susceptibility mapping of Huntingtons disease at 7 Tesla

Clare B Poynton 1 , Janine M Lupo 1 , Christopher P Hess 1 , and Sarah J Nelson 1,2

1 Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, United States, 2 Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, United States

Quantifying iron deposition in Huntingtons disease and other neurodegenerative disorders may provide insight into disease pathogenesis, aid in patient diagnosis or evaluating response to treatment. Iron accumulation changes the tissue magnetic susceptibility, which can be quantified from the MR signal phase using quantitative susceptibility mapping (QSM). In this study, we apply the QSIP algorithm to quantify magnetic susceptibility in premotor Huntingtons patients imaged at 7 Tesla. Results show statistically significant increases in QSM estimates in the caudate, putamen and globus pallidus relative to controls, which is consistent with hypothesized disease-related iron deposition in these regions.

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