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Abstract #0895

Magnetic Susceptibility Contrast Variations in Multiple Sclerosis (MS) Lesions Observed at 7T

Xu Li 1,2 , Hongjun Liu 1,3 , Daniel M Harrison 4 , Craig K Jones 1,2 , Jiwon Oh 4 , Peter A Calabresi 4 , and Peter C.M. van Zijl 1,2

1 F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 2 Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3 Radiology, Guangdong General Hospital, Guangzhou, Guangdong, China, 4 Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States

White matter magnetic susceptibility contrasts in MS were investigated using gradient echo magnitude, R2*, frequency, and quantitative susceptibility mapping (QSM). For QSM, both hyperintense (increased susceptibility) and isointense lesions were observed. A larger proportion (88.3%) of periventricular lesions were hyperintense, while a larger proportion (74.6%) of subcortical lesions were isointense. Increased lesion susceptibility may indicate either iron deposition or demyelination, while decreased R2* suggests myelin loss or low iron concentration. All R2* lesions appeared darker than normal white matter and all susceptibility lesions brighter or isointense, suggesting myelin loss as the dominant pathologic mechanism accounting for the observed findings.

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