Meeting Banner
Abstract #0859

Molecular Signaling Pathway Intervention of Fibrotic Alterations of Myo-architecture of Rabbit External Anal Sphincter Muscle following Surgical Myotomy a DTI Fiber Tracking Study.

Shantanu Sinha 1 and M. Raj Rajasekaran 2

1 Radiology, University of California San Diego, San Diego, CA, United States, 2 Gastroenterology, San Diego VA Health Care System, San Diego, CA, United States

DTI and Fiber Tracking were used to characterize in a rabbit model, the architecture of external anal sphincter (EAS) muscle in (i) intact form, (ii) recovering untreated from surgical myotomy and, (iii) same as (ii) but treated with a pharmacological intervention of Wnt antagonist, SFRP-2. In (i) and (iii) tensors showed very homogenous well-ordered distribution while fiber tracking yielded long, continuous fibers, in contrast to the untreated (ii) which showed very heterogeneous tensor parameters and short fibers. Thus DTI and FT could demonstrate fibrosis in untreated muscle recovering from injury as well as its reversal by molecular signaling pathway intervention.

This abstract and the presentation materials are available to members only; a login is required.

Join Here