Abstract #0846
Metabolic Changes in a Rat Glioma Model After Anti-Angiogenic Treatment Measured by MR Spectroscopic Imaging of Hyperpolarized [1-13C]Pyruvate
Jae Mo Park 1 , Sonal Josan 1 , Taichang Jang 2 , Milton Merchant 2 , Ralph Hurd 3 , Dirk Mayer 4 , Lawrence Recht 2 , and Daniel Spielman 1
1
Radiology, Stanford University, Stanford,
CA, United States,
2
Neurology
and Neurological Sciences, Stanford University,
Stanford, CA, United States,
3
GE Healthcare,
CA, United States,
4
Diagnostic
Radiology and Nuclear Medicine, University of Maryland,
MD, United States
We hypothesize that, in addition to changes in
permeability, anti-VEGF drug also acutely and
temporarily forces increased oxidative phosphorylation
in glioma tissue due to nutrient depletion, increasing
tumor vulnerability. Using an optimized 13C MRS imaging
sequence, we were able to reproducibly image 13C-Bic in
addition to 13C-Lac labeling using hyperpolarized
[1-13C]Pyr in tumor-bearing rats, reflecting oxidative
phosphorylation and glycolysis, respectively. After
anti-VEGF treatment, Lac/Bic decreased significantly (at
3h post-treatment) and gradually increased back (24h and
48h post-treatment) in glioma while Lac/Bic did not have
metabolic perturbation due to the drug. The increased
Lac/Bic at 24h and 48h relatve to 3h suggests this might
be a temporary phenomenon. We suggest that real time Bic
measurements may provide both a useful biomarker for
anti-angiogenic therapies and a potentially exploitable
therapeutic strategy.
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