Abstract #0843
In Vivo Monitoring of Caspase-3 Activity with MRI in Response to Different Treatment Modalities
Kimberly Brewer 1 , Adam J Shuhendler 1 , Deju Ye 1 , Prachi Pandit 1 , Magdalena Bazalova 2 , Edward Graves 2 , Jianghong Rao 1 , and Brian K Rutt 1
1
Radiology, Molecular Imaging Program,
Stanford University, Stanford, California, United
States,
2
Radiation
Oncology, Stanford University, Stanford, California,
United States
Our group has previously reported on the development of
a novel MRI caspase-3 activatable contrast agent based
on intramolecular cyclization. Introduced into the
system as small molecules, it cyclizes and
self-assembles into Gd-nanoaggregates inside of target
cells. We investigated caspase-3 activity (and thus
apoptotic cells) in two different but common treatment
modalities, chemotherapy and radiation therapy, that
induce apoptosis in cancer cells. We found significant
MRI signal enhancement for both sets of treated mice,
each with distinct intratumoral localization. By
studying the differences in caspase activity and
localization we can explore the efficiency of these
clinically relevant cancer treatments.
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