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Abstract #0842

Hypoxia and HIF silencing dysregulates total choline, CD44 expression, and metastatic burden in MDA-MB-231 human breast cancers

Balaji Krishnamachary 1 , Santosh Kumar Bharti 1 , Marie-France Pennet 1 , Samata M Kakkad 1 , Flonne Wildes 1 , Keve Zoltani 1 , Yelena Mironchik 1 , and Zaver M Bhujwalla 1

1 Radiology, Johns Hopkins University, Baltimore, MD, United States

Hypoxic tumors frequently exhibit an aggressive phenotype due to dysregulated gene expression and metabolic changes. Cancers typically exhibit elevated phosphocholine mostly due to increased choline kinase expression and activity. Here we have established a relationship between hypoxia inducible factor (HIF) and choline distribution in vivo, and have shown that silencing both HIF-1α and HIF-2α reduces total choline and metastatic burden. We have identified a role for CD44, a breast cancer stem-like cell marker, in lung colonization

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