Abstract #0832
Subtypes of nucleus accumbens activations for anticipation of gains and losses in healthy and depressed subjects
Masaya Misaki 1 , Teresa Victor 1 , Hideo Suzuki 1 , Kent Teague 2 , Brent McKinney 3 , Patrick Bellgowan 1,4 , Jonathan Savitz 1,4 , Wayne Drevets 1,5 , and Jerzy Bodurka 1,6
1
Laureate Institute for Brain Research,
Tulsa, OK, United States,
2
Dept.
of Surgery, University of Oklahoma College of Medicine,
OK, United States,
3
Dept. of Mathematical and
Computer Sciences, University of Tulsa, OK, United
States,
4
Dept.
of Medicine, Tulsa School of Community Medicine,
University of Tulsa, OK, United States,
5
Janssen
Pharmaceuticals, LLC, of Johnson & Johnson, Inc.,
Titusville, NJ, United States,
6
College
of Engineering, University of Oklahoma, OK, United
States
Subtypes of nucleus accumbens (NAcc) activation for
anticipation of gains and losses were identified for
healthy and major depressive disorder (MDD) subjects. We
used hierarchical clustering analysis to categorize NAcc
activation patterns in individual subjects. Majority of
subjects had typical NAcc activity; increased activity
to gain and less active to loss. Hyper- and hypo-active
subtypes were also found, which showed increase or
decreased activity to both gains and losses. These
hyper- and hypo-active types were seen in both healthy
and MDD groups with the same percentage. In MDD
subjects, however, subjects with the hypo-active NAcc
had more severe depression symptoms.
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