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Abstract #0828

Non-Invasive in vivo Measurements of Inertial Forces in Muscle using Phase Contrast Magnetic Resonance Imaging

Andrew L Wentland 1 , Emily J McWalter 2 , Saikat Pal 3 , Scott L Delp 3 , and Garry E Gold 2,3

1 Medical Physics, University of Wisconsin School of Medicine & Public Health, Madison, WI, United States, 2 Radiology, Stanford University, Stanford, CA, United States, 3 Bioengineering, Stanford University, Stanford, CA, United States

The purpose of this study was to create a novel tool for computing muscle forces non-invasively in vivo. Cross-sectional images of the forearms and lower legs of healthy volunteers were acquired with a fat/water separation technique as well as 2D phase contrast MRI during 1 Hz cycles of flexion/relaxation. Forces were derived from these images. Results indicate that this technique provides the ability to quantify inertial forces rather than applied forces. As a result, this technique provides the first known method for quantifying inertial forces. This analysis technique may be useful in evaluating muscle pathophysiology and further developing biomechanical models.

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