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Abstract #0768

On the origins of chemical exchange saturation transfer (CEST) contrast in tumors at 9.4T

Junzhong Xu 1 , Mortiz Zaiss 2 , Zhongliang Zu 1 , Hua Li 1 , Jingping Xie 1 , Daniel F Gochberg 1 , Peter Bachert 2 , and John C Gore 1

1 Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee, United States, 2 German Cancer Research Center, Heidelberg, Germany

A new three-offset 1/Z method was proposed to correct spillover, MT and R1 (the longitudinal relaxation rate) effects in chemical exchange saturation transfer (CEST) imaging. The corrected APT in tumors was found not significantly different from normal tissues, but corrected NOE effects in tumors showed significant decreases compared with normal tissues. These results are consistent with biochemical measurements suggesting that there is no significant enhancement of protein contents in the tumors. Our results may assist better understanding the contrast depicted by CEST imaging in tumors, and the development of improved APT and NOE measurements for cancer imaging.

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