Meeting Banner
Abstract #0674

Intracerebral drug delivery treatment using a regularly-structured biodegradable gel for slow-release of gadolinium-containing nano-micelles in a glioblastoma model

Daisuke Kokuryo 1 , Peng Mi 2,3 , Tomoka Kurita 4 , Teruyuki Yatabe 4 , Horacio Cabral 2 , Sayaka Shibata 1 , Yoshihiro Muragaki 5 , Hiroshi Iseki 5 , Takamasa Sakai 2 , Ung-il Chung 2 , Nobuhiro Nishiyama 3 , Tsuneo Saga 1 , Ichio Aoki 1 , and Kazunori Kataoka 2,6

1 Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Chiba, Japan, 2 Graduate School of Engineering, The University of Tokyo, Tokyo, Japan, 3 Chemical Resources Laboratory, Tokyo Institute of Technology, Kanagawa, Japan, 4 R&D Headquarters, Terumo Corporation, Kanagawa, Japan, 5 Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, Tokyo, Japan, 6 Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

A strategy using for providing efficient intracerebral drug delivery treatment was developed and evaluated using a combination of regularly-structured biodegradable gel and Gd-containing micelles. The Gd-micelles are slowly released from the gel for several days in vitro. For an in vivo glioblastoma model, the micelles with the gel did not show any leakage to the ventricle and the micelles were slowly and continuously released from the gel for 2-3 days. We conclude that the proposed strategy has the potential to provide effective brain tumor treatment.

This abstract and the presentation materials are available to members only; a login is required.

Join Here