Abstract #0674
Intracerebral drug delivery treatment using a regularly-structured biodegradable gel for slow-release of gadolinium-containing nano-micelles in a glioblastoma model
Daisuke Kokuryo 1 , Peng Mi 2,3 , Tomoka Kurita 4 , Teruyuki Yatabe 4 , Horacio Cabral 2 , Sayaka Shibata 1 , Yoshihiro Muragaki 5 , Hiroshi Iseki 5 , Takamasa Sakai 2 , Ung-il Chung 2 , Nobuhiro Nishiyama 3 , Tsuneo Saga 1 , Ichio Aoki 1 , and Kazunori Kataoka 2,6
1
Molecular Imaging Center, National Institute
of Radiological Sciences, Chiba, Chiba, Japan,
2
Graduate
School of Engineering, The University of Tokyo, Tokyo,
Japan,
3
Chemical
Resources Laboratory, Tokyo Institute of Technology,
Kanagawa, Japan,
4
R&D
Headquarters, Terumo Corporation, Kanagawa, Japan,
5
Institute
of Advanced Biomedical Engineering and Science, Tokyo
Women's Medical University, Tokyo, Japan,
6
Graduate
School of Medicine, The University of Tokyo, Tokyo,
Japan
A strategy using for providing efficient intracerebral
drug delivery treatment was developed and evaluated
using a combination of regularly-structured
biodegradable gel and Gd-containing micelles. The Gd-micelles
are slowly released from the gel for several days in
vitro. For an in vivo glioblastoma model, the micelles
with the gel did not show any leakage to the ventricle
and the micelles were slowly and continuously released
from the gel for 2-3 days. We conclude that the proposed
strategy has the potential to provide effective brain
tumor treatment.
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