Abstract #0673
Convection Enhanced Delivery of Toca 511 into Recurrent GBM Under Real-Time MR Guidance
Alastair Martin 1 , Manish Aghi 2 , Adrian Kells 2 , John Bringas 2 , Paul Larson 2 , Geoffrey Bates 3 , Peter Piferi 3 , Douglas Jolly 4 , Joan Robbins 4 , Derek Ostertag 4 , Carlos Ibanez 4 , Harry Gruber 4 , Krystof Bankiewicz 2 , and Daniel Pertschuk 4
1
Radiology and Biomedical Imaging, UCSF, San
Francisco, CA, United States,
2
Neurological
Surgery, UCSF, CA, United States,
3
MRI
Interventions, Irvine, CA, United States,
4
Tocagen,
San Diego, CA, United States
Intra-operative MR methods are employed to administer an
investigational retroviral replicating vector (vocimagene
amiretrorepvec; Toca 511) in a series of 7 patients with
GBM. MR targeting is employed to insert a stepped
infusion cannula to selected sites within the tumor. The
vector is infused via convection enhanced delivery and
real-time intra-operative MR monitoring of the infusion
process is achieved by mixing the vector with an MR
contrast agent. Good volumetric coverage of the tumors
was achieved, with minimal extra-tumoral extension or
reflux along the cannula tract evident.
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