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Abstract #0587

Acute lesion topography relationship with clinical admission symptoms and long-term functional outcomes in stroke patients

Ona Wu 1 , Lisa Cloonan 2 , Steven Mocking 1 , Mark Bouts 1 , Jonathan Rosand 2 , Karen L. Furie 2 , and Natalia S. Rost 2

1 Athinoula A Martinos Center, Massachusetts General Hospital, Boston, MA, United States, 2 Department of Neurology, Massachusetts General Hospital, Boston, United States

Neuroimaging is often proposed as a potential surrogate for clinical outcome in the evaluation of novel stroke therapies. We analyzed 480 patients from a prospective single center stroke data repository using voxel-based symptom mapping (VLSM) techniques with acute DWI lesions and follow-up modified Rankin Scale Score and NIH Stroke Scale Score. We found acute lesions in the left hemisphere were associated with poor outcome. VLSM methods may provide insight into patients at risk of poor long-term outcome and provide guidance towards which patients will most likely benefit from aggressive acute intervention and follow-up physical therapy.

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