Abstract #0576
Association between CVR impairment and cortical thinning in children with sickle cell disease
Junseok Kim 1,2 , Jackie Leung 2 , Jason Lerch 3 , Suzan Williams 4 , and Andrea Kassner 1,2
1
Medical Imaging, University of Toronto,
Toronto, Ontario, Canada,
2
Physiology
and Experimental Medicine, The Hospital for Sick
Children, Toronto, Ontario, Canada,
3
MICe,
Toronto Center for Phenogenomics, Toronto, Ontario,
Canada,
4
Haematology,
The Hospital for Sick Children, Toronto, Ontario, Canada
Sickle cell disease (SCD) is a genetic disorder
associated with severe cerebrovascular risks and may
also disrupt neurological development. Cerebrovascular
reactivity (CVR) can assess cerebrovascular health in
SCD children. Studies have shown grey matter thinning in
SCD children suggesting a connection to neurocogntive
decline. We investigated whether CVR is associated with
cortical thinning in children with SCD. CVR and grey
matter thickness (from T1 anatomical) data were acquired
in 42 SCD patients and 15 controls on a 3T MRI. We found
a linear relation between the degree of cortical
thinning and reduced CVR in multiple regions in the
brain.
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