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Abstract #0575

Nigral iron deposition in LRRK2 and Parkin mutation carriers using R2* relaxometry

Nadya Pyatigorskaya 1,2 , Michael Sharman 2 , Jean-Christophe Corvol 2,3 , Romain Valabregue 2,3 , Fabrice Poupon 4 , Florence Cornier 2 , Marie Vidailhet 3 , Alexis Brice 2 , and Stephane Lehricy 1,2

1 Centre de NeuroImagerie de Recherche CENIR, ICM; Service de Neuroradiologie, Groupe Hospitalier Piti-Salptrire, Paris, France, 2 Institut du Cerveau et de la Moelle pinire ICM, Paris, France, 3 CRICM, INSERM, UPMC Univ Paris 06, CNRS, CRICM, UMR_S975 and UMR 7225, Paris, France, 4 NeuroSpin, Commissariat lEnergie Atomique (CEA), Gif-Sur-Yvette, France

Our goal was investigating iron deposition in the basal ganglia of patients with Leucine-rich repeat kinase 2 and Parkin-mutation associated Parkinsons disease (PD). 19 affected and presymptomatic mutation-carrying subjects were compared with 20 idiopathic PD (IPD) and 20 healthy subjects. R2 and R2* values were calculated in the substantia nigra (SN), the basal ganglia and the thalamus. R2* values in SN were increased in IPD and mutation-carrying subjects as compared to controls and in mutation-carrying as compared to IPD patients. These results suggest that iron load, analyzed with R2* can be a biomarker of the nigrostriatal damage in mutation-carrying subjects.

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